Synthesis of a chiral aziridine derivative as a versatile intermediate for HIV protease inhibitors.

Article abstract of DOI:10.1021/ol016147s

[reaction: see text] Chiral aziridine derivative 1 was prepared from D-tartaric acid. This compound could be utilized as a common intermediate for the synthesis of hydroxyethylamine class HIV protease inhibitors such as saquinavir, amprenavir, or nelfinavir.