Monastrol, a 3,4-dihydropyrimidin-2(1H)-thione, as structural scaffold for the development of modulators for GHB high-affinity binding sites and α1β2δ GABAA receptors

Article abstract of DOI:10.1016/j.ejmech.2017.06.024

The α₄βδ subtype of the γ-aminobutyric acid (GABA) type A receptors (GABA_ARs) has been shown to be implicated in high-affinity binding of the neuromodulator γ-hydroxybutyric acid (GHB), but may not be the only GHB high-affinity bindi