Studies on reactions of nucleoside H-phosphonates with bifunctional reagents. Part VI. Reaction with diols

Article abstract of DOI:10.1080/15257770008045441

Reactions of nucleoside H-phosphonates with various diols using different types of condensing agents have been studied. Depending on the coupling procedure and the length of a polymethylene chain of the diol, acyclic H-phosphonate diesters or cyclic phosphite triesters were formed. The course of oxidation with iodine to produce cyclic nucleoside alkyl phosphotriesters or hydroxyalkyl nucleoside phosphodiesters can be controlled by the amount of water present in the reaction medium.

Full text of DOI:10.1080/15257770008045441

This article was downloaded by: [University of Exeter]
On: 04 August 2015, At: 13:26
Publisher: Taylor & Francis
Informa Ltd Registered in England and Wales Registered Number: 1072954 Registered
office: 5 Howick Place, London, SW1P 1WG
Nucleosides, Nucleotides and Nucleic
Acids
Publication details, including instructions for authors and
subscription information:
http://www.tandfonline.com/loi/lncn20
Studies on Reactions of Nucleoside
H-Phosphonates with Bifunctional
Reagents. Part VI. Reaction with Diols
Michal Sobkowski a , Malgorzata Wenska a , Adam Kraszewski a &
Jacek Stawiński a b
a Institute of Bioorganic Chemistry, Polish Academy of Sciences ,
Noskowskiego 12/14, 61-704, Poznan, Poland
b Stockholm University, Arrhenius Laboratory, Department of Organic
Chemistry , S-10691, Stockholm, Sweden
Published online: 17 Apr 2008.
To cite this article: Michal Sobkowski , Malgorzata Wenska , Adam Kraszewski & Jacek Stawiński
(2000) Studies on Reactions of Nucleoside H-Phosphonates with Bifunctional Reagents. Part VI.
Reaction with Diols, Nucleosides, Nucleotides and Nucleic Acids, 19:10-12, 1487-1503, DOI:
10.1080/15257770008045441
To link to this article: http://dx.doi.org/10.1080/15257770008045441
PLEASE SCROLL DOWN FOR ARTICLE
Taylor & Francis makes every effort to ensure the accuracy of all the information (the
“Content”) contained in the publications on our platform. However, Taylor & Francis,
our agents, and our licensors make no representations or warranties whatsoever as to
the accuracy, completeness, or suitability for any purpose of the Content. Any opinions
and views expressed in this publication are the opinions and views of the authors,
and are not the views of or endorsed by Taylor & Francis. The accuracy of the Content
should not be relied upon and should be independently verified with primary sources
of information. Taylor and Francis shall not be liable for any losses, actions, claims,
proceedings, demands, costs, expenses, damages, and other liabilities whatsoever or
howsoever caused arising directly or indirectly in connection with, in relation to or arising
out of the use of the Content.
This article may be used for research, teaching, and private study purposes. Any
substantial or systematic reproduction, redistribution, reselling, loan, sub-licensing,
systematic supply, or distribution in any form to anyone is expressly forbidden. Terms &

Conditions of access and use can be found at http://www.tandfonline.com/page/terms-
and-conditions