Synthesis of a 3-aminopiperidin-2,5-dione as a conformationally constrained surrogate of the Ala-Gly dipeptide

DOI: 10.1016/S0040-4020(00)00990-X

Source and publish data:

Tetrahedron p. 157 - 161 (2001)

Update date:2022-07-30

Topics:

Authors:

Estiarte, M.Angels

Diez, Anna

Rubiralta, Mario

Jackson, Richard F.W

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Article abstract of DOI:10.1016/S0040-4020(00)00990-X

The preparation of the Boc-{Ala-Gly}-OBn pseudopeptide 4 is reported. The key intermediate, aminoester 5b, was obtained by a cross-coupling reaction of alaninezinc iodide 6 and the thioester of glycine 9.

Full text of DOI:10.1016/S0040-4020(00)00990-X

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