Journal of the Chinese Chemical Society p. 1267 - 1272 (2000)
Update date:2022-08-05
Topics: Characterization Purification Data Analysis Scale-up Design Iterative Process Safety and Regulatory Considerations Synthetic Routes Reagents and Starting Materials
Soleiman
Khalafallah
Abdelzaher
A series of fused and spiro pyrazolones, pyrimidinthiones,thiazolidinones and β-lactams incorporating benzoindole derivatives have been synthesised by cyclocondensation addition reaction and cycloaddition reaction of hydrazine hydrate, hydroxylamine, thiourea, mercapto acetic acid and monochloroacetyl chloride. The prepared compounds were tested for antibacterial and fungicidal activity. Gram-negative bacteria (Bacillus cereus), as well as the fungus was used for this purpose. The biological assay was determined according to the filter paper disc method. Assay plates were incubated at 30°C one day for the bacteria and three days for the fungus (British pharmacopoeia commisson, 1102m, London 1963). The test results show that the components have a strong and satisfactory effect.
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