Safety and Regulatory Considerations

Functionalization Characterization Lysergic acid Ergot alkaloids Radical cyclisation Tri-n-butyltin hydride Terminal phenylthio group Indolyl unit Annulation reactions LDA AcCl HF MnO2 Ph3P=CH(OMe) 13X mol. sieves Optimization Biological testing Purification Data Analysis Starting Material Purification and characterization Materials and Reagents Chemical Synthesis Structure-Activity Relationship (SAR) Studies In Vivo Testing Formulation and Delivery Scale-up Mechanism of Action Publication and Patenting Design Iterative Process Design and Planning Macrocyclization Bioassays β3-Adrenoceptor Agonist Activity Testing Synthetic Routes Toxicity and Specificity Testing Rational Design Radical Cyclization Start with a suitable precursor Generate radical intermediates Understanding Quorum Sensing (QS) Identification of Target Bacteria Natural Product Screening Reagents and Starting Materials Synthesis of Carbazole Derivatives