Bioorganic and Medicinal Chemistry Letters p. 1103 - 1107 (2002)
Update date:2022-08-05
Topics:
Mehrotra, Mukund M.
Heath, Julie A.
Rose, Jack W.
Smyth, Mark S.
Seroogy, Joseph
Volkots, Deborah L.
Ruhter, Gerd
Schotten, Theo
Alaimo, Lisa
Park, Gary
Pandey, Anjali
Scarborough, Robert M.
The synthesis and biological activity of analogues containing spiro piperidinylpyridine and pyrrolidinylpyridine templates are described. The potent activity of these compounds as platelet aggregation inhibitors demonstrates the utility of the spiro structures as central template for nonpeptide RGD mimics.
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