Investigation into the preferred conformation of Gabapentin for interaction with its binding site on the α2δ subunit of a calcium channel

Article abstract of DOI:10.1016/S0960-894X(97)10002-6

A series of conformationally restricted Gabapentin analogues has been synthesised and used to propose the preferred conformation of Gabapentin for it to bind to the α₂δ subunit of a calcium channel.