Bioorganic and Medicinal Chemistry Letters p. 5241 - 5246 (2005)
Update date:2022-08-05
Topics:
Macdonald, Dwight
Mastracchio, Anthony
Perrier, Helene
Dube, Daniel
Gallant, Michel
Lacombe, Patrick
Deschenes, Denis
Roy, Bruno
Scheigetz, John
Bateman, Kevin
Li, Chun
Trimble, Laird A.
Day, Stephen
Chauret, Nathalie
Nicoll-Griffith, Deborah A.
Silva, Jose M.
Huang, Zheng
Laliberte, France
Liu, Susana
Ethier, Diane
Pon, Doug
Muise, Eric
Boulet, Louise
Chi, Chung Chan
Styhler, Angela
Charleson, Stella
Mancini, Joseph
Masson, Paul
Claveau, David
Nicholson, Donald
Turner, Mervyn
Young, Robert N.
Girard, Yves
The discovery and SAR of a new series of substituted 8-arylquinoline PDE4 inhibitors are herein described. This work has led to the identification of several compounds with excellent in vitro and in vivo profiles, including a good therapeutic window of em
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