Synthesis of a common key intermediate for (-)-tetrodotoxin and its analogs

DOI: 10.1016/S0040-4020(01)00258-7

Source and publish data:

Tetrahedron p. 3875 - 3883 (2001)

Update date:2022-08-03

Topics:

Authors:

Nishikawa, Toshio

Asai, Masanori

Ohyabu, Norio

Yamamoto, Noboru

Fukuda, Yoshio

Isobe, Minoru

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Article abstract of DOI:10.1016/S0040-4020(01)00258-7

A key intermediate for tetrodotoxin and its analogs such as (-)-5,11-dideoxytetrodotoxin was stereoselectively synthesized from a chiral starting material, levoglucosenone, via Diels-Alder reaction and the Overman rearrangement as key steps. The Overman r

Full text of DOI:10.1016/S0040-4020(01)00258-7

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