Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)- methanes as N-type calcium channel blockers

DOI: 10.1016/S0960-894X(99)00404-7

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2447 - 2452 (1999)

Update date:2022-09-26

Topics:

Authors:

Schelkun, Robert M.

Yuen, Po-wai

Malone, Thomas C.

Rock, David M.

Stoehr, Sally

Szoke, Balazs

Tarczy-Hornoch, Katalin

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Article abstract of DOI:10.1016/S0960-894X(99)00404-7

Voltage activated calcium channel (VACC blockers have been demonstrated to have utility in the treatment of stroke and pain. A series of aminomethyl substituted phenol derivatives has been identified with good functional activity and selectivity for N-typ

Full text of DOI:10.1016/S0960-894X(99)00404-7

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Product name:4,4'-(2-amino-ethylidene)-di-phenol; hydrochloride

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