Synthesis and structure-activity relationships of (R)-1-alkyl-3-[2-(2- amino)phenethyl]-5-(2-fluorophenyl)-6-methyluracils as human GnRH receptor antagonists

Article abstract of DOI:10.1016/j.bmcl.2004.02.004

The synthesis of a series of (R)-1-alkyl-3-[2-(2-amino)phenethyl]-5-(2- fluorophenyl)-6-methyluracils is discussed. SAR around N-1 of the uracil was explored, which led to the discovery that an electron-deficient 2,6-disubstituted benzyl group is required