Synthesis of some new unsymmetrical 1,4-dihydropyridine derivatives as potent antitubercular agents

Article abstract of DOI:10.1515/HC.2001.7.5.481

2,6-Dimethyl-3-acetyl-5-carbmethoxy-4-(3′nitrophenyl)-1,4- dihydropyridine 1 was condensed with aromatic and heterocyclic aldehydes to form chalcone analogs 2a-h and then cyclised to substituted pyrazolines leading to novel 1,4-dihydropyridine 3a-h, 4a-h and 5a-h which are directly attached to heterocyclic moiety and devoid of the ester function at C₃ (of DHP). All compounds were screened for their antitubercular activity against Mycobacterium tuberculosis (H₃₇Rv).

Full text of DOI:10.1515/HC.2001.7.5.481

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Download Date | 6/14/15 11:06 PM