Heterocyclic Communications p. 481 - 484 (2001)
Update date:2022-09-26
Topics:
Gevariya, Harsukh
Desai, Bhavik
Vora, Vipul
Shah, Anamik
2,6-Dimethyl-3-acetyl-5-carbmethoxy-4-(3′nitrophenyl)-1,4- dihydropyridine 1 was condensed with aromatic and heterocyclic aldehydes to form chalcone analogs 2a-h and then cyclised to substituted pyrazolines leading to novel 1,4-dihydropyridine 3a-h, 4a-h and 5a-h which are directly attached to heterocyclic moiety and devoid of the ester function at C3 (of DHP). All compounds were screened for their antitubercular activity against Mycobacterium tuberculosis (H37Rv).
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