Kinetics and Catalysis p. 397 - 400 (2011)
Update date:2022-08-05
Topics:
Gang, Li
Ruiling, Long
Jiangli, Yang
One-pot three-component Mannich reactions of ketones with aromatic aldehydes and aromatic amines are effectively catalyzed by molecular iodine at room temperature under solvent-free conditions to afford the corresponding β-amino carbonyl compounds with moderate to excellent yields. The method has the following advantages: no use of solvent, mild condition, high reaction speed and small quantity of catalyst.
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