Design and evaluation of new antipsoriatic antedrug candidates having 16-en-22-oxa-vitamin D3 structures

Article abstract of DOI:10.1016/j.bmcl.2006.03.014

Design, synthesis, and in vitro and in vivo evaluation of a series of antipsoriatic antedrugs having 16-en-22-oxa-vitamin D₃ are described. Among the seven compounds examined, two are promising: ester 5c and amide 5f, both of which exhibit grea