Tetrahedron p. 9019 - 9034 (1991)
Update date:2022-08-05
Topics:
Schummer, Anita
Yu, Hongtao
Simon, Helmut
Various (R)-2-hydroxy acids such as (R)-2-hydroxy-3-enoic-, 3,5-dienoic-, 4-oxo-, (R,S)-3-hydroxy and some others were prepared on a scale up to 0.12 mol by biocatalytic reduction of the corresponding 2-oxo acids with P. vulgaris and hydrogen gas and/or formate as electron donors.With the exception of the 2-hydroxy-4-oxo acids it could be proved that the enantiomeric excess is >97 percent.For the 4-oxo derivatives this enantiomeric excess can be assumed.The yields of isolated products are high because they were isolated from rather small amounts of biocatalyst and low buffer concentrations.Product concentrations in the range of 0.1- 0.24 M were obtained.For 1 mmol of product formation in 15-20 h about 20-40 mg (dry weight) of P. vulgaris cells are necessary.
View MoreWuxi Forest Biological Co.,Ltd
Contact:+86-510-81602300
Address:Room 317,Building D, No.159 middle Chengjiang Road,Jiangyin Wuxi city.
Shijiazhuang Haotian Chemical Co., Ltd.
Contact:86-311-85044374
Address:293 Donggang Road
Shandong Wanda Organosilicon New Material Co., Ltd
Contact:+86-21-54177116;54302881
Address:R1318 Greenland No. 3 Lane 58 Xinjian East Rd., Minhang
jiangsu haian chemical co.,ltd.
Contact:86-513-15851283853
Address:No.99,Changjiang West Road,Haian County,Jiangsu Province,China
Jiaozuo Zhongwen Trading Coporation Limited
Contact:+86 0391-3553810
Address:East Renmin Road
Doi:10.1016/S0022-328X(01)00863-4
(2001)Doi:10.1039/jr9490002323
(1949)Doi:10.1016/S0022-1139(00)85033-2
(1990)Doi:10.1016/j.bmc.2007.01.048
(2007)Doi:10.1021/jm00247a018
(1974)Doi:10.1039/b103553n
(2001)