Sorbicillinol, a key intermediate of bisorbicillinoid biosynthesis in Trichoderma sp. USF-2690.

Article abstract of DOI:10.1271/bbb.65.2271

In the course of our screening program for free radical scavengers from Trichoderma sp. USF-2690, we found an unidentified metabolite (1) that appeared by the method used for HPLC analysis. Metabolite 1 gradually decreased with the production of bisorbicillinoids and was easily missed during the general isolation procedure. The LC-ESI-MS (negative) analysis for 1 gave m/z 247 as the (M-1)- ion peak. The hydrolysis of synthetic 6-O-acetylsorbicillinol (+/- -2) by 0.05 M KOH and acetylation of product 1 in an aqueous solution indicated that the structure of 1 was (6S)-4-(2,4-hexadienoyl)-3,6-dihydroxy-2,6-dimethyl-2,4-cyclohexadien-1-one, designated sorbicillinol, a quinol that has been postulated to be important in bisorbicillinoid biosynthesis.

Full text of DOI:10.1271/bbb.65.2271

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Sorbicillinol, a Key Intermediate of Bisorbicillinoid
Biosynthesis in Trichoderma sp. USF-2690
Naoki ABEa, Osamu SUGIMOTOa, Tadaharu ARAKAWAa, Ken-ichi TANJIa & Akira HIROTAa
a School of Food and Nutritional Sciences, University of Shizuoka
Published online: 22 May 2014.
To cite this article: Naoki ABE, Osamu SUGIMOTO, Tadaharu ARAKAWA, Ken-ichi TANJI & Akira HIROTA (2001) Sorbicillinol,
a Key Intermediate of Bisorbicillinoid Biosynthesis in Trichoderma sp. USF-2690, Bioscience, Biotechnology, and
Biochemistry, 65:10, 2271-2279, DOI: 10.1271/bbb.65.2271
To link to this article: http://dx.doi.org/10.1271/bbb.65.2271
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