Beating the hydrogen bond: First selective and high-yielding N-acylation process for an α,β-diaminoalcohol

Article abstract of DOI:10.1021/op0601464

The first selective and high-yielding N-acylation of an α,β-diaminoalcohol is reported, as well as the first use as N-acylation agent of a 5-mercaptobenzothiazolyl thioester of an α,β-unsaturated carboxylic acid. Other conventional coupling methods (acid