Modified steroids 103. Splitting of the 17-C-N bond of 16,17α-epimino-20-ketgsteroids and their 20-hydrazones by reaction with thioacetic acid

Article abstract of DOI:10.1007/BF00923591

1. The reactions of 16,17 α-eplminopregn-5-en-3 β-ol-20-one and its 20-carbethoxyhydrazone with thioacetic acid proceed with different stereochemical direction of scission of the aziridine ring at the tertiary 17-C atom. Schemes to explain the differences are proposed. 2. A new class of heterocyclic compounds, 2′-methyl-[16,17α-d]-thiazoline 20-ketosteroids, has been obtained.