Synthesis and biological activity of new 2-amino-4-[3-methyl-3-(5,6,7,8- tetrahydro-2-naphthyl)cyclobutyl]thiazole derivatives

Article abstract of DOI:10.1007/s11178-005-0105-2

2-Amino-4-[3-methyl-3-(5,6,7,8-tetrahydro-2-naphthyl)cyclobutyl]thiazole was synthesized by reaction of 1-methyl-1-(5,6,7,8-tetrahydro-2-naphthyl)-3- chloroacetylcyclobutane with thiourea in ethanol, and its subsequent transformations afforded new derivatives which were tested in vitro for antibacterial activity against some bacteria using the disk diffusion technique.