New serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptor antagonists: Synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl)benzo and heterocycloalkanones

DOI: 10.1021/jm011014y

Source and publish data:

Journal of Medicinal Chemistry p. 54 - 71 (2002)

Update date:2022-08-03

Topics:

Authors:

Brea Brea

Rodrigo Rodrigo

Carrieri

Sanz Sanz

Cadavid Cadavid

Enguix Enguix

Villazón

Mengod Mengod

Caro Caro

Masaguer

Ravi?a Ravi?a

Centeno Centeno

Carotti Carotti

Loza Loza

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Article abstract of DOI:10.1021/jm011014y

A series of 52 conformationally constrained butyrophenones have been synthesized and pharmacologically tested as antagonists at 5-HT_2A, 5-HT_2B, and 5-HT_2C serotonin receptors, useful for dissecting the role of each 5-HT View More

Full text of DOI:10.1021/jm011014y

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