Bioorganic and Medicinal Chemistry Letters p. 6264 - 6269 (2011)
Update date:2022-08-03
Topics:
Qian, Yimin
Ahmad, Mushtaq
Chen, Shaoqing
Gillespie, Paul
Le, Nam
Mennona, Frank
Mischke, Steven
So, Sung-Sau
Wang, Hong
Burghardt Charles
Tannu, Shahid
Conde-Knape, Karin
Kochan, Jarema
Bolin, David
Through high throughput screening and subsequent hit identification and optimization, we synthesized a series of 1-arylcarbonyl-6,7- dimethoxyisoquinoline derivatives as the first reported potent and reversible GFAT inhibitors. SAR studies of this class o
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