Chemistry of Natural Compounds p. 355 - 361 (1992)
Update date:2022-09-26
Topics:
Kuranova, I. L.
Churkina, S. I.
Os'mak, A. V.
Filonova, E. B.
Lyudmirova, V. L.
Noskova, O. V.
A peptide fragment with the 140-146 sequence of the main component of the surface protein of the hepatitis B virus (HBsAG) and a number of its structural analogues have been synthesized by the classical method in solution.Conjugates of the peptides synthesized with bovine serum albumin and with a synthetic polypeptide analogue of polytuftsin have been obtained.The ability of the preparations to bind antibodies from the blood sera of hepatitis B patients has been studied.The possibility has been shown of their use for revealing antibodies to the heptatitis B virus in solid-phase enzyme-mediated immunoassay.
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