SYNTHESIS AND PROPERTIES OF PEPTIDE FRAGMENTS OF THE S-REGION OF THE SURFACE PROTEIN OF THE HEPTATITIS B VIRUS

Article abstract of DOI:10.1007/BF00630258

A peptide fragment with the 140-146 sequence of the main component of the surface protein of the hepatitis B virus (HBsAG) and a number of its structural analogues have been synthesized by the classical method in solution.Conjugates of the peptides synthesized with bovine serum albumin and with a synthetic polypeptide analogue of polytuftsin have been obtained.The ability of the preparations to bind antibodies from the blood sera of hepatitis B patients has been studied.The possibility has been shown of their use for revealing antibodies to the heptatitis B virus in solid-phase enzyme-mediated immunoassay.