A new entry of highly selective and nucleophilic BrH2C-and CLH2c-titanium complexes for carbonyl coupling

Article abstract of DOI:10.1002/ejoc.201801438

The direct coupling of various aldehydes and ketones with CH₂Br₂ or CH₂Cl₂ promoted by TiCl₄-Mg bimetallic complex provides an extremely simple, practical, and efficient approach for the construction of bromomethyl or chloromethyl carbinols. The high chemoselectivity of this chemistry is illus-trated by the TiCl₄-Mg-promoted selective coupling of CH₂Br₂ or CH₂Cl₂ with an aldehyde in the presence of ketone and selective transfer of CH₂Br or CH₂Cl to saturated carbonyl moiety. This protocol is also suitable for sterically hindered and enoliza-ble carbonyl compounds.