Novel ceramide 1-sulfates, potent DNA topoisomerase I inhibitors isolated from the bryozoa Watersipora cucullata

DOI: 10.1016/S0040-4039(97)00852-6

Source and publish data:

Tetrahedron Letters p. 4235 - 4238 (1997)

Update date:2022-07-29

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Authors:

Ojika, Makoto

Yoshino, Go

Sakagami, Youji

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Article abstract of DOI:10.1016/S0040-4039(97)00852-6

Two ceramide 1-sulfates 1 and 2 have been isolated from the Japanese Bryozoa Watersipora cucullata as new potent inhibitors of a human DNA topoisomerase I. The gross structures of 1 and 2 were determined by spectroscopic analysis, and their absolute stereochemistry was elucidated by the optical data of degradation products.

Full text of DOI:10.1016/S0040-4039(97)00852-6

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