Novel ceramide 1-sulfates, potent DNA topoisomerase I inhibitors isolated from the bryozoa Watersipora cucullata

Article abstract of DOI:10.1016/S0040-4039(97)00852-6

Two ceramide 1-sulfates 1 and 2 have been isolated from the Japanese Bryozoa Watersipora cucullata as new potent inhibitors of a human DNA topoisomerase I. The gross structures of 1 and 2 were determined by spectroscopic analysis, and their absolute stereochemistry was elucidated by the optical data of degradation products.