
Journal of Organometallic Chemistry p. 155 - 159 (1999)
Update date:2022-07-30
Topics:
Boga, Carla
Del Vecchio, Erminia
Forlani, Luciano
Milanesi, Lilia
Edgardo Todesco, Paolo
The reaction between 2-lithio derivatives of aromatic azaheterocycles and trichlorocetyl derivatives rapidly produces the corresponding 2-chloro derivatives in high yields through a metal-halogen exchange mechanism. The use of ethyl trichloroacetate can give better results with respect to those obtained with trichloroacetyl chloride, which probably involves dichloroketene formation. The reaction with Grignard reagents is more complex: in fact, 2-benzothiazolylmagnesium chloride with ethyl trichloroacetate or trichloroacetyl chloride gives 2-chlorobenzothiazole together with considerable amounts of ethyl 1,3-benzothiazole-2-carboxylate or 2-benzothiazolyl dichloromethyl ketone, respectively.
View MoreZhejiang Allied Chemical Co.,Ltd
Contact:18967038207
Address:Area A-30, High-tech Industrial Park, Quzhou, Zhejiang, China.
Zhejiang kehong chemical co., ltd
Contact:0086-575-85522000
Address:xiner center RD binhai industrial zone shaoxing zhejiang province P.R.China,312073
Contact:+31-24-3886056
Address:Binderskampweg 29 Unit 36
Jinan YouCheng Pharmatech Co.,Ltd
Contact:+86-18653163205
Address:No.750, Shunhua Road, University Science Park, High-tech Zone, Jinan City
Contact:+86-22-83718541
Address:32th Floor, Rongqiao Center Intersection of Changjiang Road and Nankai Six Road Nankai District Tianjin 300102, China
Doi:10.1039/a810006c
(1999)Doi:10.1021/jm990383f
(2000)Doi:10.1016/j.tetlet.2003.09.131
(2003)Doi:10.1021/jm00263a042
(1973)Doi:10.1016/S0040-4039(99)01391-X
(1999)Doi:10.1021/jo00223a031
(1985)