Research on Chemical Intermediates p. 6433 - 6441 (2015)
Update date:2022-08-04
Topics:
Ma, Er-Qian
Wang, Ping
Li, Pei-He
Mo, Li-Ping
Abstract A convenient three-step procedure has been developed for synthesis of substituted 2-aminobenzophenones from substituted anilines. The anilines are first protected as acetanilides, by reaction with acetic anhydride. These are then benzoylated with (trichloromethyl)benzene in the presence of aluminium-generated 2-acetamidobenzophenone. Finally, removal of the acetyl group from the amino group provides the substituted 2-aminobenzophenones in moderate to good yields.
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