Bioorganic Chemistry (2020)
Update date:2022-07-31
Topics:
Liu, Honghui
Wang, Yan
Lv, Mingxia
Luo, Yi
Liu, Bu-Ming
Huang, Yan
Wang, Mian
Wang, Jianyi
A series of novel flavonoid analogues were designed and synthesized. The aimed compounds for urease inhibitory activities were clearly superior to the control drug thiourea (more than 10 times). Among these compounds, L2 (IC50 = 1.343 μM) and L12 (IC50 = 1.207 μM) exhibited the most excellent urease inhibitory activity in vitro. The molecular dockings of L2, L12 and L22 into urease were performed to explore the binding modes and their structure-activity relationship. Furthermore, these aimed compounds showed good druggable properties.
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