Cytotoxicity and actin depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and the natural and artificial analogs

DOI: 10.1016/S0960-894X(96)00620-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 269 - 274 (1997)

Update date:2022-08-05

Topics: Cytotoxicity Artificial analogs Aplyronine A

Authors:

Suenaga, Kiyotake

Kamei, Noriyuki

Okugawa, Youko

Takagi, Masaki

Akao, Atsushi

Kigoshi, Hideo

Yamada, Kiyoyuki

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Article abstract of DOI:10.1016/S0960-894X(96)00620-8

The artificial analogs of aplyronine A (1), a potent cytotoxic and antitumor macrolide, were synthesized and the structure-activity (cytotoxicity and actin depolymerizing activity) studies were performed; the side chain portion in 1 was found to play a key role in both biological activities.

Full text of DOI:10.1016/S0960-894X(96)00620-8

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