Cytotoxicity and actin depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and the natural and artificial analogs

DOI: 10.1016/S0960-894X(96)00620-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 269 - 274 (1997)

Update date:2022-08-05

Topics: Cytotoxicity Artificial analogs Aplyronine A

Authors:

Suenaga, Kiyotake

Kamei, Noriyuki

Okugawa, Youko

Takagi, Masaki

Akao, Atsushi

Kigoshi, Hideo

Yamada, Kiyoyuki

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(96)00620-8

The artificial analogs of aplyronine A (1), a potent cytotoxic and antitumor macrolide, were synthesized and the structure-activity (cytotoxicity and actin depolymerizing activity) studies were performed; the side chain portion in 1 was found to play a key role in both biological activities.

Full text of DOI:10.1016/S0960-894X(96)00620-8

Products guided by the article

Product name:C₇₉H₁₄₈O₁₃SSi₄

Cas No:423771-98-6

R&D Labs maybe for 423771-98-6

Zhejiang Allied Chemical Co.,Ltd

Contact:18967038207

Address:Area A-30, High-tech Industrial Park, Quzhou, Zhejiang, China.
Shreeji pharma international

Contact:0091-265-2313036

Address:311, ATLANTIS HEIGHTS SARABHAI MAIN ROAD,VADIWADI ,VADODARA
Shenzhen Hongyuan Import & Export Co., Ltd.

Contact:0755-26407171

Address:Shenzhen Hongyuan Chemical New Materials Technology Co., Ltd.
Weifang Ocean Trading Co., Ltd.

Contact:+86-536-2081155

Address:Room2606, Yuqing Building, 518#, Yuquan Road, High-tech Development Zone, Weifang City, Shandong Province, China
Onlychem (Jinan)Biotech Co.,Ltd

Contact:86-531-83175885

Address:No. 44, Honglou South Road, Jinan,China

Relevant to this article

Practical synthesis of 1,12-difunctionalized o-carborane for the investigation of polar liquid crystals

Doi:10.1021/ic5014494
(2014)
Biological and structure-activity evaluation of chalcone derivatives against bacteria and fungi

Doi:10.1590/S0103-50532013000100018
(2013)
Synthesis and reactivity of η⁵-germacyclopentadienyl complexes of iron

Doi:10.1021/om0110991
(2002)
Doi:10.1021/ja01299a017
(1936)
Synthesis, characterization and the thermal isomerization mechanism of a series of trans-tetracarbonyl-bis(phosphinite)molybdenum(0) complexes and an evaluation of their potential to form heterobimetallic compounds

Doi:10.1016/j.jorganchem.2013.10.015
(2014)
Nucleic acid components and their analogues. CLVIII. Preparation of some substituted 2 amino and 2 mercaptopyrimidines from trimethinium salts

Doi:10.1135/cccc19731371
(1973)

Article Doi