Bioorganic and Medicinal Chemistry Letters p. 269 - 274 (1997)
Update date:2022-08-05
Suenaga, Kiyotake
Kamei, Noriyuki
Okugawa, Youko
Takagi, Masaki
Akao, Atsushi
Kigoshi, Hideo
Yamada, Kiyoyuki
The artificial analogs of aplyronine A (1), a potent cytotoxic and antitumor macrolide, were synthesized and the structure-activity (cytotoxicity and actin depolymerizing activity) studies were performed; the side chain portion in 1 was found to play a key role in both biological activities.
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