Synthesis and biological evaluation of acylthiourea against DUSP1 inhibition

DOI: 10.1016/j.bmcl.2019.05.021

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1746 - 1748 (2019)

Update date:2022-07-31

Topics:

Authors:

Yeon Kim, Bo

Hee Yoon, Ji

Kim, Myeongbin

Nyoung Kim, Jae

Park, Hwangseo

Eon Ryu, Seong

Lee, Sangku

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Article abstract of DOI:10.1016/j.bmcl.2019.05.021

Structure based virtual screening attempts to discover DUSP1 inhibitors have yielded a scaffold featuring benzoxazole and acylthiourea pharmacophore. A series of its analogues were synthesized to explore structure activity relationship (SAR) of DUSP1 inhi

Full text of DOI:10.1016/j.bmcl.2019.05.021

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Product name:N-(4-bromobenzoyl)-N'-[3-(5-chloro-1,3-benzoxazol-2-yl)phenyl]thiourea

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