THE SYNTHESIS OF L-α-AMINOADIPYL-L-CYSTEINYL-D-3,4-DIDEHYDROVALINE, A POTENT INHIBITOR OF ISOPENICILLIN SYNTHETASE

Article abstract of DOI:10.1016/0040-4020(82)85002-3

The title peptide (1) has been synthesized and incubated with an active cell-free extract of Cephalosporium acremonium, no conversion to active antibiotics was observed; however on co-incubation with the Arnstein tripeptide (ACV) (2), strong inhibition of