Tetrahedron Letters p. 3046 - 3049 (2016)
Update date:2022-08-05
Topics: Synthesis Characterization Yield Reagents Catalyst Analog Inhibitor Purification Novel Synthesis Experimental conditions Physovenine Physostigmine
Wang
Alluri
Nikogosyan
Decarlo
Monteiro
Mabagos
Feng
White
Bartolini
Andrisano
Zhang
Ganguly
This Letter describes a versatile synthetic approach to prepare physovenine and physostigmine analogs. A series of analogs were synthesized and evaluated for cholinesterase inhibition activities, including human acetylcholinesterase (AChE) and butyrylchol
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