Bioorganic and Medicinal Chemistry Letters p. 3064 - 3066 (2018)
Update date:2022-08-04
Topics:
Fan, Yi-Lei
Wu, Jian-Bing
Ke, Xing
Huang, Zhong-Ping
A series of oxime-functionalized nitrofuranylamides were designed, synthesized and evaluated for their in vitro anti-mycobacterial activities against MTB H37Rv and drug-resistant clinical isolates. Among them, two compounds 7a and 7b exhibited excellent activity against the three tested strains. Both of them were comparable to the first-line anti-TB agents INH and RIF against MTB H37Rv, and were far more potent than INH and RIF against MDR-TB 16833 and 16995 strains. Thus, both of them could act as leads for further optimization.
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