Bioorganic and Medicinal Chemistry Letters p. 3064 - 3066 (2018)
Update date:2022-08-04
Topics:
Fan, Yi-Lei
Wu, Jian-Bing
Ke, Xing
Huang, Zhong-Ping
A series of oxime-functionalized nitrofuranylamides were designed, synthesized and evaluated for their in vitro anti-mycobacterial activities against MTB H37Rv and drug-resistant clinical isolates. Among them, two compounds 7a and 7b exhibited excellent activity against the three tested strains. Both of them were comparable to the first-line anti-TB agents INH and RIF against MTB H37Rv, and were far more potent than INH and RIF against MDR-TB 16833 and 16995 strains. Thus, both of them could act as leads for further optimization.
View MoreSPRING CHEMICAL INDUSTRY CO.,LTD
Contact:86-187-66672125
Address:linchi industry park.zouping
Nanjing Capatue Chemical Co., Ltd
Contact:+86-25-86371192 +86-025-85720158
Address:No.20 Jiangjun Avenue, Jiangning Economic & Technical Development Zone
Lishui Nanming Chemical Co., Ltd(expird)
Contact:+86-0578-2134101,2697830
Address:No.19 Tongji Road Shuige Industrial zone
Shandong Xiangde Biotechnology Co., Ltd
Contact:+86 -15066639877
Address:Sanba street
Shanghai Dano Pharmaceutical Co.,Ld.(expird)
Contact:+86-592-6266840
Address:Building 1 Room 512, 720 Cailun Rd, Zhangjiang High-Tech Park, Shanghai 201203, China
Doi:10.1039/c2cc31214j
(2012)Doi:10.1021/ol300872e
(2012)Doi:10.1016/0040-4039(91)80030-A
(1991)Doi:10.1002/ejoc.202001425
(2021)Doi:10.1055/s-0031-1289670
(2012)Doi:10.1016/j.tet.2012.03.039
(2012)