Bioorganic and Medicinal Chemistry Letters p. 4973 - 4978 (2005)
Update date:2022-08-05
Topics:
Fisher, Matthew J.
Backer, Ryan T.
Collado, Ivan
De Frutos, Oscar
Husain, Saba
Hsiung, Hansen M.
Kuklish, Steve L.
Mateo, Ana I.
Mullaney, Jeffrey T.
Ornstein, Paul L.
Paredes, Cristina Garcia
O'Brian, Thomas P.
Richardson, Timothy I.
Shah, Jikesh
Zgombick, John M.
Briner, Karin
Replacement of the aryl piperazine moiety in compound 1 with a variety of substituted benzylic piperazines (6) yields compounds that afford melanocortin receptor 4 (MCR4) activity. Analogs with ortho substitution on the aromatic ring afforded the highest
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