ASYMMETRIC SYNTHESIS XIV: A SHORT AND EFFICIENT SYNTHESIS OF 3,5-DISUBSTITUTED PYRROLIZIDINE ALKALOIDS VIA THE CN(R,S) METHOD

Article abstract of DOI:10.1016/S0040-4039(00)80305-6

The enantiospecific synthesis of the dextrorotatory enantiomer of the ant venom alkaloid 3-heptyl-5-methylpyrrolidine 11 has been achieved in four steps and 31percent overall yield from the chiral 2-cyano-5-oxazolopyrrolidine synthon 4.On the basis of pre