Synthetic Communications p. 989 - 999 (2002)
Update date:2022-08-05
Topics:
Shalaby, Alyaa A.
El-Shahawi, Manal M.
Shams, Nabil A.
Batterjee, Suzan
3,4-Diethoxycarbonyl-5,6-diphenylpyridazine 1 reacted with hydrazine hydrate to form tetrahydropyridazino [4,5-c]pyridazine 2, which reacted with ethyl bromoacetate to give 6,7-diethoxycarbonylmethyl-3,4-diphenyl-5,8-dioxopyridazino [4,5-c]pyridazine 3. However, acetylation of 2 with acetyl chloride gave three different pyridazino[4,5-c]pyridazines 4-6. The reaction of the starting diester 1 with different amounts of phenylmagnesium bromide gave different products 7-10. The structure of product 8 was elucidated by alkaline hydrolysis and hydrazinolysis to afford 11 and 13, respectively. Treatment of 13 with benzaldehyde in piperidine yielded the starting Grignard product 8 and benzalazine 17.
View MoreContact:+86-25-85281586
Address:13F,Bld2#,South of Longpan Road
Shanghai Sunwise Chemical Co., Ltd
website:http://www.sunwisechem.com
Contact:86-021-33883180
Address:Room 10E, Building G, Westlink Center, No. 2337 Gudai Road, Minhang District, Shanghai, China PC: 201100
QINGDAO NEW FLOURISH INTERNATIOANAL TRADE CO., LTD.
Contact:+86 532 80861829
Address:No. 1, Yinchuan East Road, 266061, Qingdao, China
Hubei Lingsheng Pharmaceuticals Co., Ltd.
Contact:+86-0710-3538058
Address:Xiangyang City Xiangcheng Economic Development Zone, Hubei Province
Contact:86-511-85210668 0511-85210668, 85210818, 85210898
Address:Yihai Garden E-902,NO.99 Daxi RD., Zhenjiang Jiiangsu ,China
Doi:10.1021/ja00863a026
(1962)Doi:10.1021/jm020211+
(2002)Doi:10.1021/om0202930
(2002)Doi:10.1039/c2ob26067k
(2012)Doi:10.1021/jm7010657
(2008)Doi:10.1002/chem.200500119
(2005)