Synthesis of functionalized hydroxy-thiophene motifs as amido- and sulfonamido-phenol bioisosteres

DOI: 10.1016/j.tetlet.2009.06.085

Source and publish data:

Tetrahedron Letters p. 5005 - 5008 (2009)

Update date:2022-07-30

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Authors:

Chao, Jianhua

Taveras, Arthur G.

Aki, Cynthia J.

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Article abstract of DOI:10.1016/j.tetlet.2009.06.085

Novel highly substituted hydroxy thiophene motifs were designed and synthesized as viable amido phenol and sulfonamido phenol bioisosteres. Hydroxy group-directed regioselective bromination and palladium-catalyzed amination of thienyl bromide via Buckwald

Full text of DOI:10.1016/j.tetlet.2009.06.085

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