Wharton-fragmentation-based approach to the carbocyclic core of the phomoidrides

DOI: 10.1021/ol302011b

Source and publish data:

Organic Letters p. 4544 - 4547 (2012)

Update date:2022-07-29

Topics:

Authors:

Murphy, Graham K.

Hama, Naoto

Bedermann, Aaron

Dong, Ping

Schneider, Chris M.

McMahon, Travis C.

Tao, Ran N.

Twenter, Barry M.

Spiegel, David A.

Wood, John L.

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Article abstract of DOI:10.1021/ol302011b

The carbocyclic core of the phomoidrides has been synthesized efficiently and in high yield. Key steps include a phenolic oxidation/intramolecular Diels-Alder sequence, tandem radical cyclization, and a late-stage Wharton fragmentation of a densely functionalized isotwistane skeleton.

Full text of DOI:10.1021/ol302011b

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