The phosphonic analogues of threonine and β-phenylserine: Preparation and analysis of stereoisomers

Article abstract of DOI:10.1080/10426509808029670

The simple procedures for the preparation of 1-amino-2-hydroxypropanephosphonic (3) and 1-amino -2-hydroxy-2-phenylethane phosphonic (4) acids in acceptable yields are described. We showed by NMR studies with chiral Pr(hfc)₃ shift reagent and by HPLC that the reactions are not stereospecific and both products constitute a mixture of all feasible stereoisomers. The crystal structure of the racemic (3) was also determined by X-Ray.

Full text of DOI:10.1080/10426509808029670

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Phosphorus, Sulfur, and Silicon
and the Related Elements
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THE PHOSPHONIC
ANALOGUES OF THREONINE
AND β-PHENYLSERINE:
PREPARATION AND ANALYSIS OF
STEREOISOMERS
Ewa Matczak-jon a , Józef Barycki b , Malgorzata
Milewska b & Wanda Sawka-dobrowolska c
a Institute of Inorganic Chemistry
b Institute of Organic Chemistry, Biochemistry and
Biotechnology, Wroclaw University of Technology ,
50-370, Wroclaw
c Department of Chemistry , University of Wroclaw ,
50-383, Wroclaw, Poland
Published online: 24 Sep 2006.
To cite this article: Ewa Matczak-jon , Józef Barycki , Malgorzata Milewska &
Wanda Sawka-dobrowolska (1998) THE PHOSPHONIC ANALOGUES OF THREONINE
AND β-PHENYLSERINE: PREPARATION AND ANALYSIS OF STEREOISOMERS,
Phosphorus, Sulfur, and Silicon and the Related Elements, 142:1, 101-115, DOI:
10.1080/10426509808029670
To link to this article: http://dx.doi.org/10.1080/10426509808029670
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