Bioorganic and Medicinal Chemistry Letters p. 2403 - 2406 (2002)
Update date:2022-08-04
Topics:
Kim, Hea Ok
Park, Yong Hee
Moon, Hyung Ryong
Jeong, Lak Shin
Novel D-2′-azido-2′,3′-dideoxyarabinofuranosyl-4′- thiopyrimidines and purines have been synthesized, starting from L-xylose via azidation at the 2′-position as a key step. Most of the final nucleosides exhibited toxicity-dependent anti-HIV-1 activity, among which D-α-adenine analogue 3h was found to be the most cytotoxic.
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Doi:10.1002/1099-0682(200210)2002:10<2730::AID-EJIC2730>3.0.CO;2-G
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