On rearrangements by cyclialkylations of arylpentanols to 2,3-dihydro-1H-indene derivatives. Part 1. An unexpected rearrangement by the acid-catalyzed cyclialkylation of 4-(2-chlorophenyl)-2,4-dimethyl pentan-2-ol under formation of trans-4-chloro-2,3-dih

DOI: 10.1002/1522-2675(200206)85:6<1827::AID-HLCA1827>3.0.CO;2-J

Source and publish data:

Helvetica Chimica Acta p. 1827 - 1840 (2002)

Update date:2022-08-04

Topics: Rearrangement Acid-Catalyzed Aryl cyclialkylation

Authors:

Blum, Roger

Giovannini, Edgardo

Hengartner, Urs

Vallat, Gabriel

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Article abstract of DOI:10.1002/1522-2675(200206)85:6<1827::AID-HLCA1827>3.0.CO;2-J

The acid-catalyzed cyclialkylation of 2,4-dimethyl-4-phenylpentan-2-ol led exclusively to the expected product, 2,3-dihydro-1,1,3,3-tetramethyl-1H-indene. However, analogous cyclialkylation of 4-(2-chlorophenyl)-2,4-dimethylpentan-2-ol (1) gave a ca. 1:1

Full text of DOI:10.1002/1522-2675(200206)85:6<1827::AID-HLCA1827>3.0.CO;2-J

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