Bioorganic and Medicinal Chemistry Letters p. 3558 - 3561 (2007)
Update date:2022-08-04
Topics:
Liang, Gui-Bai
Qian, Xiaoxia
Feng, Dennis
Fisher, Michael
Brown, Christine M.
Gurnett, Anne
Leavitt, Penny Sue
Liberator, Paul A.
Misura, Andrew S.
Tamas, Tamas
Schmatz, Dennis M.
Wyvratt, Matthew
Biftu, Tesfaye
Diaryl imidazo[1,2-a]pyridine derivatives, such as 6a and 7i, have been synthesized and found to be potent inhibitors of parasite PKG activity. The most potent compounds are the 7-isopropylaminomethyl analog 6a and 2-isopropylamino analog 7i. These compounds are also fully active in in vivo assay as anticoccidial agents at 25 ppm in feed.
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