Substituted piperazines as novel dipeptidyl peptidase IV inhibitors

DOI: 10.1016/j.bmcl.2004.06.065

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 4763 - 4766 (2004)

Update date:2022-07-29

Topics:

Authors:

Brockunier, Linda L.

He, Jiafang

Colwell Jr., Lawrence F.

Habulihaz, Bahanu

He, Huaibing

Leiting, Barbara

Lyons, Kathryn A.

Marsilio, Frank

Patel, Reshma A.

Teffera, Yohannes

Wu, Joseph K.

Thornberry, Nancy A.

Weber, Ann E.

Parmee, Emma R.

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Article abstract of DOI:10.1016/j.bmcl.2004.06.065

The synthesis and SAR of a series of piperazines containing a fluorophenyl β-amino amide moiety is reported. Incorporation of a fluorophenyl β-amino amide moiety into piperazine screening lead 2 has resulted in the discovery of a structurally novel series

Full text of DOI:10.1016/j.bmcl.2004.06.065

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