Facile β-alkyl and β-hydride elimination in the nickel-catalyzed annulation of o-iodophenyl ketones and aldehydes with bicyclic alkenes

DOI: 10.1021/ol061051p

Source and publish data:

Organic Letters p. 2867 - 2869 (2006)

Update date:2022-08-03

Topics:

Authors:

Shukla, Paritosh

Cheng, Chien Hong

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Article abstract of DOI:10.1021/ol061051p

o-Iodoaryl aldehydes react with bicyclic alkenes in the presence of NiBr₂(dppe) and Zn powder in acetonitrile at 80 °C undergoing annulation to give polycyclic ketone derivatives. Surprisingly, o-iodoaryl alkyl ketones also react with bicyclic

Full text of DOI:10.1021/ol061051p

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