Journal of Medicinal Chemistry p. 1110 - 1113 (1982)
Update date:2022-08-04
Topics:
Houlihan, William J.
Cooke, George
Bochoven, Richard Van
Perrine, John
Takesue, Edward I.
Jukniewicz, E.
A series of 8-aryl-5-isopropyl-2H-1,3-dioxolo<4,5-g>quinazolin-6(5H)-ones and -thiones was prepared and evaluated for antiinflammatory activity.The 8-phenyl-, 8-(3-fluorophenyl)-, and 8-(4-fluorophenyl)-2H-1,3-dioxolo<4,5-g>quinazolin-6(5H)-ones and the 8-phenyl-2H-1,3-dioxolo<4,5-g>quinazolin-6(5H)-thione were found to exhibit activity in the range of indomethacin and proquazone.
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