European Journal of Medicinal Chemistry p. 743 - 754 (2002)
Update date:2022-08-05
Topics: Synthesis Derivatives Antibacterial activity Experimental terms HPLC (High Performance Liquid Chromatography) Carbapenem Antimicrobial assay Thiazolo
Oh, Chang-Hyun
Cho, Han-Won
Baek, Daejin
Cho, Jung-Hyuck
The synthesis of a new series of 1β-methylcarbapenems having the substituted thiazolopyrrolidine moiety is described. Their in vitro antibacterial activities against both Gram-positive including MRSA and Gram-negative bacteria were tested and the effect of substituent on the thiazole ring was investigated. A particular compound (28c) having 4′-amide substituted thiazole moiety showed the most potent antibacterial activity.
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