Radical cyclization to aporphines. A new, efficient total synthesis of the aporphine glaucine and the 4,5-dioxoaporphine pontevedrine, and the first total synthesis of 5-oxoaporphines

Article abstract of DOI:10.1016/S0040-4020(01)85073-0

We describe the radical cyclization of bromobenzylisoquinolines and benzylisoquinolin-3-ones, which afford aporphines or the novel 5-oxoaporphines and 5-oxodehydroaporphines respectively. Oxidation of the latter compounds provides a new route to 4,5-dioxoaporphines.