Journal of the American Chemical Society p. 482 - 483 (1988)
Update date:2022-08-05
Topics:
Williams, Robert M.
Sinclair, Peter J.
Zhai, Weixu
Bromoglycinate 4 was coupled with the (trimethylsilyl)ketene acetal of dibenzyl malonate to furnish predominantly the syn-lactone 6.Hydrogenolysis of 6 directly afforded β carboxyaspartic acid (Asa) in 30percent overall yield in >98percent ee.The optical purity of the synthetic Asa was determined by decarboxylation and esterification to aspartic acid diethyl eester.
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