Journal of the American Chemical Society p. 482 - 483 (1988)
Update date:2022-08-05
Topics:
Williams, Robert M.
Sinclair, Peter J.
Zhai, Weixu
Bromoglycinate 4 was coupled with the (trimethylsilyl)ketene acetal of dibenzyl malonate to furnish predominantly the syn-lactone 6.Hydrogenolysis of 6 directly afforded β carboxyaspartic acid (Asa) in 30percent overall yield in >98percent ee.The optical purity of the synthetic Asa was determined by decarboxylation and esterification to aspartic acid diethyl eester.
View MoreGuangxi Nanning Guangtai Agriculture Chemical Co.,Ltd
Contact:+86-771-2311266
Address:Room703,Building12, Software Park Phase II,NO.68,Keyuan Road,Nanning City,Guangxi,China
Heliosense Biotechnologies, Inc.
website:https://www.heliosense.com/
Contact:+86-592-5667290
Address:Xiamen Torch Hi-tech Zone Venture Weiye Building S506
Shouguang Nuomeng Chemical Co., Ltd.
Contact:+86-536-5119508/18363669993
Address:Hou Zhen Industrial Park, Shouguang, Shandong, China
Contact:0086-29-88315623
Address:S711, Innovation Bldg No.25 Gaoxin 1st Rd, Xian P.R of China 710075
PharmaResources(Kaiyuan)CO,.Ltd
Contact:+86-21-50720028
Address:No.3, Beihuan Road, Economic Development District, Kaiyuan City, Tieling City, Liaoning Province, China 112300
Doi:10.1002/adsc.202000397
(2020)Doi:10.1021/acs.orglett.7b01679
(2017)Doi:10.1021/acs.jmedchem.6b00685
(2016)Doi:10.1063/1.2189456
(2006)Doi:10.1016/0040-4039(95)01311-5
(1995)Doi:10.1021/ol800261j
(2008)
