
Tetrahedron p. 7691 - 7702 (1996)
Update date:2022-08-05
Topics:
Oberhauser, Thomas
Meduna, Vladimir
(±)-7-Aminocephalosporanic acid (18a) and (±)-7-epi- aminocephalosporanic acid (4a) have been synthesized. A chiral HPLC method has been developed for the separation of the four stereo-isomers. Natural (+)-7-aminocephalosporanic acid (1) was demonstrated to he enantiomerically (ee >> 99.95%) and diastereomerically (de >>99.95%) pure.
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