Nonsteroidal selective glucocorticoid modulators: The effect of C-10 substitution on receptor selectivity and functional potency of 5-allyl-2,5-dihydro-2,2,4-trimethyl-lh-[1]benzopyrano[3,4-f]quinolines

DOI: 10.1021/jm020335m

Source and publish data:

Journal of Medicinal Chemistry p. 1016 - 1030 (2003)

Update date:2022-09-26

Topics:

Authors:

Kym, Philip R.

Kort, Michael E.

Coghlan, Michael J.

Moore, Jimmie L.

Tang, Rui

Ratajczyk, James D.

Larson, Daniel P.

Elmore, Steven W.

Pratt, John K.

Stashko, Michael A.

Douglass Falls

Lin, Chun W.

Nakane, Masake

Miller, Loan

Tyree, Curtis M.

Miner, Jeffery N.

Jacobson, Peer B.

Wilcox, Denise M.

Nguyen, Phong

Lane, Benjamin C.

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Article abstract of DOI:10.1021/jm020335m

The preparation and characterization of a series of C-10 substituted 5-allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines as a novel class of selective ligands for the glucocorticoid receptor is described. Substitution at the C-10 positi

Full text of DOI:10.1021/jm020335m

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